The most common benign brain tumor is meningioma, a benign tumor that develops from the surface of the dura mater between the brain and bone.
Meningioma is generally a benign tumor that can be cured by surgical removal, but if it is located deep in the brain or has important nerves or blood vessels around it, it may be difficult to completely remove it. It is important to predict whether there is a high likelihood of regrowth after surgery.
A pathological examination is performed on the tumor cells collected during surgery, and if there are many dividing cells, the recurrence rate may be high.
In collaboration with Dr. Takamitsu Fujimaki, current professor of neurosurgery at Saitama Medical University, and Dr. Akira Matsuno, current deputy director and supervising professor at International University of Health and Welfare, I performed craniotomy to remove the tumor and performed reoperation for postoperative recurrence. Using pathological specimens of 29 cases of meningioma that we performed, we examined the MIB-1 index, which is an index of tumor cell division (if formalin specimens are available, it can be examined many years after surgery), Published in Cancer, one of the most prestigious English-language journals in oncology, demonstrating an inverse relationship between time to double volume (tumor doubling time) and MIB-1. (Cancer1999;85:2249-54. Impact Factor 2015=9.329).MIB-1 & recurrent meningioma.pdf

These studies triggered the use of MIB-1 as a pathological test around the world, and the MIB-1 index is still considered the most important pathological test for examining tumor growth potential.
In addition, this paper is quoted with a figure in "Brain Tumor Therapeutics (Kinpodo 2016)" written as a culmination after retirement by Dr. Masao Matsutani, Professor Emeritus of Saitama Medical University, who has been a driving force in the world's brain tumor treatment for many years. It has been. It is a great honor to have my paper selected as one of the 2130 carefully selected references from around the world in textbooks considered to be the bible of brain tumor treatment.
Tumor doubling time prediction formula: log Td= 31.4 – 0.14 × MIB SI R-squared = 0.556 (P< 0.0001)